SCHEDULE 13D

CUSIP No. 7171EP101

Page 1of 5 Pages

UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

SCHEDULE 13D

Under the Securities Exchange Act of 1934

(Amendment No. 3)

PHARMACOPEIA, INC.

____________________________________________________________________________________

(Name of Issuer)

Common Stock, $0.01 par value

____________________________________________________________________________________

(Title of Class of Securities)

7171EP101

_______________________________________________________

(CUSIP Number)

David J. Harris, Esq., 1775 Eye Street, N.W. Washington, D.C. 20006 (202) 261-3385

____________________________________________________________________________________

(Name, Address and Telephone Number of Person Authorized to Receive Notices and Communications)

September 11, 2008

______________________________________________________

(Date of Event which Requires Filing of this Statement)

If the filing person has previously filed a statement on Schedule 13G to report the acquisition which is the subject of this Schedule 13D, and is filing this schedule because of Rule 13d-1(b)(3) or (4), check the following box o.

The information required on the remainder of this cover page shall not be deemed to be “filed” for the purpose of Section 18 of the Securities Exchange Act of 1934 (“Act”) or otherwise subject to the liabilities of that section of the Act but shall be subject to all other provisions of the Act (however, see the Notes).

SCHEDULE 13D

CUSIP No. 7171EP101

Page 2of 5 Pages

NAME OF REPORTING PERSON

Josiah T. Austin

CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (a) o (b) x

SEC USE ONLY

SOURCE OF FUNDS

CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDING IS REQUIRED PURSUANT TO ITEMS 2(d) or 2(e) o

CITIZENSHIP OR PLACE OF ORGANIZATION

United States

NUMBER OF

SHARES

BENEFICIALLY

OWNED BY

EACH

REPORTING

PERSON

WITH

SOLE VOTING POWER

1,180,172 Shares

SHARED VOTING POWER

2,859,792 Shares

SOLE DISPOSITIVE POWER

1,180,172 Shares

SHARED DISPOSITIVE POWER

2,859,792 Shares

AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

4,039,964 Shares

CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES) o

PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

13.58 %

TYPE OF REPORTING PERSON

SCHEDULE 13D

CUSIP No. 7171EP101

Page 3 of 5 Pages

NAME OF REPORTING PERSON

El Coronado Holdings, L.L.C.

CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (a) o (b) x

SEC USE ONLY

SOURCE OF FUNDS

CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDING IS REQUIRED PURSUANT TO ITEMS 2(d) or 2(e) o

CITIZENSHIP OR PLACE OF ORGANIZATION

Arizona

NUMBER OF

SHARES

BENEFICIALLY

OWNED BY

EACH

REPORTING

PERSON

WITH

SOLE VOTING POWER

Not Applicable

SHARED VOTING POWER

2,859,792 Shares

SOLE DISPOSITIVE POWER

Not applicable

SHARED DISPOSITIVE POWER

2,859,792 Shares

AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

2,859,792 Shares

CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES o

PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

9.61%

TYPE OF REPORTING PERSON

SCHEDULE 13D

CUSIP No. 7171EP101

Page 4 of 5 Pages

ITEM 1. Security and Issuer

This amendment No. 3 to the Statement on Schedule 13D heretofore filed on December 10, 2007 is filed with respect to the common stock, $0.01 par value (“Common Stock”), of Pharmacopeia, Inc. (the “Company”). The address of the Company is PO Box 5350, Princeton, New Jersey 08543-5350. This statement is being filed on behalf of Josiah T. Austin (“Austin”), a U.S. citizen, and El Coronado Holdings, LLC (“ECH”) an Arizona limited liability company whose principal place of business is 4673 Christopher Place, Dallas, Texas 75204 (collectively the “Reporting Persons”) to reflect the following amendments to Item 3 and Item 5.

ITEM 3.

Source and Amount of Funds or Other Consideration

(1) Acting on behalf of the J.Z. Sylvester 2006 Grandchild Gift Trust, Austin purchased on August 29, 2008, a total of 2,000 shares of Common Stock in open market transactions for an aggregate consideration (exclusive of brokers’ commissions) of $4167.90. The primary source of funds for these purchases was existing funds of the Trust.

(2) Acting on behalf of the M.K. Lowery 2006 Grandchild Gift Trust, Austin purchased on August 29, 2008, a total of 2,000 shares of Common Stock in open market transactions for an aggregate consideration (exclusive of brokers’ commissions) of $4172.48. The primary source of funds for these purchases was existing funds of the Trust.

(3) Acting on behalf of the J.A. Lowery 2006 Grandchild Gift Trust, Austin purchased on August 29, 2008, a total of 2,000 shares of Common Stock in open market transactions for an aggregate consideration (exclusive of brokers’ commissions) of $4172.00. The primary source of funds for these purchases was existing funds of the Trust.

(4) Acting on behalf of the A.L. Elias 2006 Grandchild Gift Trust, Austin purchased on August 29, 2008, a total of 2,000 shares of Common Stock in open market transactions for an aggregate consideration (exclusive of brokers’ commissions) of $4172.00. The primary source of funds for these purchases was existing funds of the Trust.

(5) Acting on behalf of the Josiah & Valer Austin Family Revocable Trust, in his capacity as Trustee, Austin purchased from September 3, 2008 to September 19, 2008 a total of 415,172 shares of Common Stock in open market transactions for an aggregate consideration (exclusive of brokers’ commissions) of $731,892.62. The primary source of funds for these purchases was existing funds of the Trust.

All dollar amounts are in U.S. dollars.

ITEM 5.

Interest in Securities of the Issuer

(a) Austin is deemed beneficial owner of 4,039,964 shares of Common Stock in his capacity as Trustee for certain family trusts and as sole Managing Member of ECH. ECH is deemed beneficial owner of 2,859,792 shares of Common Stock. Based on the 29,745,100 shares of Common Stock outstanding as of July 28, 2008, as reported in the Company’s 10-Q filed on July 31, 2008, Austin and ECH’s deemed beneficial holdings represent, respectively, 13.58% and 9.61% of the Company’s Common Stock.

(b) As Trustee for certain family trusts, Austin has the sole power to vote or to dispose or direct the disposition of 1,180,172 shares of Common Stock. As sole Managing Member of ECH, Austin shares with ECH the power to vote or dispose or to direct the disposition of 2,859,792 shares of Common Stock.

(c) No transactions in the Company’s Common Stock have been effected by the Reporting Persons since August 13, 2008 except the following transactions, each of which was made in a broker's transaction in the open market. Prices do not include brokerage fees.

SCHEDULE 13D

CUSIP No. 7171EP101

Page 5 of 5 Pages

Reporting Person	Date	No. of Shares	Price Per Share
J.Z. Sylvester 2006 Grandchild Gift Trust	8/29/2008	2,000	$2.0839
M.K. Lowery 2006 Grandchild Gift Trust	8/29/2008	2,000	$2.0862
J.A. Lowery 2006 Grandchild Gift Trust	8/29/2008	2,000	$2.086
A.L. Elias Trust dtd 4/6/06	8/29/2008	2,000	$2.086
Josiah & Valer Austin Family Revocable Trust	9/3/2008	124,633	$1.9854
Josiah & Valer Austin Family Revocable Trust	9/9/2008	51,100	$1.7598
Josiah & Valer Austin Family Revocable Trust	9/10/2008	21,600	$1.7044
Josiah & Valer Austin Family Revocable Trust	9/11/2008	105,000	$1.6836
Josiah & Valer Austin Family Revocable Trust	9/12/2008	95,000	$1.6651
Josiah & Valer Austin Family Revocable Trust	9/19/2008	17,839	$1.2749

(d) No person other than the Reporting Persons has any right to receive or the power to direct the receipt of dividends from, or proceeds from the sale of, such securities.

(e)

Not Applicable.

SIGNATURE

After reasonable inquiry and to the best knowledge and belief, I certify that the information set forth in this Statement is true, complete and correct.

Date: September 22, 2008

/s/ Josiah T. Austin

Josiah T. Austin,

Individually and as Sole Managing Member of ECH